To answer your question, for most american fuel injected engines, AFPR's are for the most part, specifc to that engine. Most of the fords are bolted (3 bolts) to the fuel rail, just like the sy/ty/gn's (2 bolts). You could use a AEM or other brand regulator, but you would have to do some mods to the rail. Your vortec's truck has the regulator under the plastic plenum in the center, and you will need some major replumbling and modifications to make it accesable for adjustability.