i dont know,Nate....a 4.3 (or even a 3.8) in that truck may not be up to the task,that truck is a bit heavier than your typical s-10...it was put in that truck as a 'worker'..they even called some of those w/t's-you can really lean on those motors(n/a) and they will last a long time...with the time & money you would spend on hopping it up you could drop a v8 in there(plenty of room) and get some real power without having to mess with the ecm,harness,exhaust(like u would a turbo),ect...
i have a 95 4.3 z motor in an s-10 4x4 that i threw a Whipple s/c on and it has plenty of power,BUT if i could go back,i would probably forgo the s/c for a v8 swap (and saved myself a couple gs).they make some killer 350 crate motors with 350hp for reasonable money (hang a turbo of it if you must and hit 450 hp easy on relatively low boost)...if money is no object,go 402 or whatever the big block of the week is...drop it in and forget it.
i have enough time & money tied up in my bitch that theres no turning back for me...and i dont mind,cause it has plenty of power...but i WOULD of done a v8 if i had any sense...hind sight is 20/20.
YES,it would be a cool conversion,and if you have the time,money,and knowledge to pull it off...go for it!! but jamming 10-15+ psi of boost down a 4.3s throat is a risky proposition (even for GMC),just be prepared for alot of trial & error...
for what its worth...
T